Dados do Trabalho

Título

Diagnostic Performance of MRI for the Detection of Pulmonary Nodules: A Systematic Review and Meta-Analysis

Descrição sucinta do(s) objetivo(s)

To perform a meta-analysis of the diagnostic performance of magnetic resonance imaging (MRI) for the detection of pulmonary nodules using computed tomography (CT) as the reference standard.

Descrição da(s) doença(s), método(s) e/ou técnica(s)

PubMed, Embase, and Scopus databases were systematically searched from January 2000 to March 2023 for studies evaluating the performance of MRI for diagnosis of lung nodules ≥4mm using CT as reference. Studies including micronodules, nodules without size stratification, or those from which data for contingency tables could not be extracted were excluded. Primary outcomes were the per-lesion sensitivity of MRI and the false positive nodules per patient (FPP). Subgroup analysis by size and meta-regression with other covariates were made. Study Registration: PROSPERO (CRD42023437509).

Discussão

10 studies met inclusion criteria, (1354 patients, 2062 CT detected nodules). MRI overall per-lesion sensitivity for nodules ≥4 mm was 87.7% (95%CI:81.1–92.2), while the FPP was 12.4% (95%CI 7.0 – 21.1). Subgroup analyses demonstrated that for nodules ≥8-10 mm, MRI sensitivity was 98.5% (95%CI:90.4–99.8), while for nodules <8mm sensitivity was 80.5% (95%CI:71.5–87.1).

Conclusões

MRI demonstrated a good overall performance for detection of pulmonary nodules ≥4mm and almost equal performance to CT for nodules ≥8-10mm with a limited FPP of 12%.

Palavras Chave

lung nodule; lung cancer; lung cancer screening.

Arquivos